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Please contact us for more information

Email: contact@holodiag.com
Phone: +33(0)2.32.40.58.26
Fax: +33(0)2.32.25.29.02

Our strengths

  • - custom-built services
  • - elaborated report
  • - swift processing
  • - expertise of our team

When you want to form new solid phases in order to have access to new physicochemical characteristics and if polymorphism and salt-formation have already been studied, co-crystals screening should be considered.

Background of the study

We investigate on known data and, when necessary, we can perform a preliminary study in order to optimize the parameters to be studied during the screening process (e.g. characteristics of the starting materials, measurement of solubilities, ...). The co-crystallizer is chosen according to specific interactions related to the structure of your molecule (H-bonds, pi-pi interactions, Van der Waals, ...).We can then direct the choices towards the most appropriate crystallization processes and build DOE accordingly.

Packages

We offer 3 different packages to fulfill your needs:

  • Focused
  • Extended
  • Custom-built

Focused

- limited number of parameters
- to get an insight of the solid phases
- affordable,
- rapid answer, swift access to the next development stage

Extended

- maximum number of co-crystallizers
- maximum number of appropriate crystallization parameters
- defined protocols and design of experiments

Custom-built

- based on your specifications, or
- joint development of crystallization protocols (temperature cycles, evaporation...) and experimental designs

Characterization

Each sample is analyzed by powder X-ray diffraction, which allows to maximize the data collected within the time lapse. Most promising candidates can be further analyzed. Analytical and experimental data retrieved during the screening process enable you to choose the "final candidates".

What you get

A screening of solid phases generates a huge amount of data. However raw data are just ... raw data. At the end of the study, Holodiag provides a high quality report: it is not just a compilation of analyses but an interpretation of the results, a highlight of the key points together with advices, and also an open discussion with our scientists.

And now ?

If the results from the screening process do not allow to narrow down the list of candidates or if you need additional data, we perform post-screening studies on stability (thermodynamic/statistic), solubility, ... You can then choose the most appropriate phase(s) according to the characteristics needed. When your best candidates have been selected, we can scale-up the process from few dozen of milligram up to the kilo lab.

Information and cost

Should you need more details or a quotation, please contact us.