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Acidic and basic moieties are widespread among pharmaceutical molecules. Measurements of pKa values are thus essential for the development of crystallization processes. It ensures the stability of the API by mastering the pH. It is also a necessary step for the formation of salts (c.f. our activities of salt selection and resolving agents).
Holodiag performs pKa measurements in aqueous solutions, in water / organic solvent mixes as well as in pure organic solvents. Data can then be extrapolated to aqueous solutions if needed.
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