Ici > le chemin > dans le site > ...

Please contact us for more information

Email: contact@holodiag.com
Phone: +33(0)2.32.40.58.26
Fax: +33(0)2.32.25.29.02

Our strengths

  • - custom-built services
  • - elaborated report
  • - swift processing
  • - expertise of our team

Crystallization screening of polymorphic forms or solvates gives the opportunity to identify a maximum number of solid phases, in order to protect the development against late stage development problems (e.g. appearing of a new phase) or to secure your intellectual property.

Screening studies give access to a huge amount of information concerning the physicochemical characteristics of your molecule (phases with a high solubility, most stable form, filtrability, compressibility, pharmacokinetics, ...).

Background of the study

We investigate on known data and, when necessary, we can perform a preliminary study in order to optimize the parameters to be studied during the screening process (e.g. characteristics of the starting materials, measurement of solubilities, ...). We can then direct the choices towards the most appropriate crystallization processes and build DOE accordingly.

Packages

We offer 3 different packages to fulfill your needs:

  • Focused
  • Extended
  • Custom-built

Focused

- limited number of parameters
- to get an insight of the solid phases
- affordable,
- rapid answer, swift access to the next development stage

Extended

- maximum number of appropriate crystallization parameters
- defined protocols and design of experiments

Custom-built

- based on your specifications, or
- joint development of crystallization protocols (temperature cycles, evaporation...) and experimental designs

Characterization

Each sample is analyzed by powder X-ray diffraction, which allows to maximize the data collected within the time lapse. Most promising candidates can be further analyzed. Analytical and experimental data retrieved during the screening process enable you to choose the "final candidates".

What you get

A screening of solid phases generates a huge amount of data. However raw data are just ... raw data. At the end of the study, Holodiag provides a high quality report: it is not just a compilation of analyses but an interpretation of the results, a highlight of the key points together with advices, and also an open discussion with our scientists.

And now ?

If the results from the screening process do not allow to narrow down the list of candidates or if you need additional data, we perform post-screening studies on stability (thermodynamic/statistic), solubility, ... You can then choose the most appropriate phase(s) according to the characteristics needed. When your best candidates have been selected, we can scale-up the process from few dozen of milligram up to the kilo lab.

Information and cost

Should you need more details or a quotation, please contact us.